Imipramine

Imipramine

Application: Treatment of depression in adults - Treatment of enuresis in children

Imipramine Drug Information

Contraindications to imipramine

Drug Interaction Imipramine

Tips to consider before taking imipramine

Possible side effects of imipramine

How to store imipramine

Imipramine Drug Information

Drug Information: Imipramine belongs to a group of drugs called tricyclic antidepressants. It is commonly used to treat depression in adults. However, imipramine is also used to treat a completely different condition in children, enuresis.

The exact cause of depression is not well known. Anyone can be at risk for depression. It can start for no apparent reason or as a result of life events such as social issues, loss of loved ones, and illness. Medications such as imipramine help reduce depressive symptoms.

Enuresis is a common disorder in children. Imipramine blocks the transmission of messages to some nerves that end in the bladder. This mechanism prevents acetylcholine from acting on its receptor. Acetylcholine causes the message to empty the bladder. Imipramine can reduce the need to urinate. Imipramine for children is prescribed by a specialist. This medicine is not suitable for children under 6 years old.

Contraindications to imipramine

• Pay attention to the expiration date of the medicine and do not take it if the medicine in your hand has expired.
• Never give imipramine to anyone else, even if you have the same symptoms.
• Do not take more imipramine than your doctor prescribes.
• Check for drug interactions and be sure to tell your doctor what other medications you are taking.
• Imipramine is hypnotic, avoid driving while taking this drug.

Drug Interaction Imipramine

It may alter the performance of medications and increase the risk of serious side effects. Make a list of all the medicines (including prescription / over-the-counter medicines and herbal products) you use and share them with your doctor and pharmacist. Do not change the dose of your medicine without consulting your doctor or stop taking the medicine.

Some of the drugs that may interact with imipramine include digoxin, disopramide, thyroid supplements, valproic acid, anticholinergic drugs (such as benztropine), belladonna alkaloids (high-pressure alkaloids), (clonidine), guanabenz, reserpine.

If you take other drugs that increase serotonin, your risk of developing serotonin syndrome or toxicity increases. Examples of these drugs include MDMA or "ecstasy", St. John's wort, certain antidepressants (including SSRIs such as fluoxetine / paroxetine, SNRIs such as duloxetine). / Venlafaxine).

Imipramine can cause serious drug interactions with MAO inhibitors, which can even lead to death. ) Do not use phenelzine, procarbazine, rasagiline, selegiline, tranylcypromine. Most MAO inhibitors should not be used until 2 weeks before taking imipramine.

Drugs that can affect the removal of imipramine from the body and affect its function include: alcohol, barbiturates (such as phenobarbital), cimetidine, cisapride, haloperidol, specific heart rhythm drugs (such as flacinide, propafenone) , Halofantrine, HIV protease inhibitors (such as fos iprenavir), phenothiazines (such as thioridazine), pimozide, some anticonvulsants (such as carbamazepine, phenytoin), terbinafine, and trazodone.

Many drugs in addition to imipramine may affect the heart rhythm (prolongation of QT time), including: amiodarone, dofetilide, pimozide, procainamide, quinidine ), Sotalol, macrolide antibiotics (such as erythromycin).

Concomitant use of imipramine may increase the risk of seizures, including isoniazid (INH), phenothiazines (such as thioridazine), theophylline, or tricyclic antidepressants (such as nortriptyline). (nortriptyline)).

Tell your doctor or pharmacist if you are taking medicines that cause drowsiness, including: alcohol, antihistamines (such as cetirizine, diphenhydramine), sleeping pills or anxiety medications (such as alprazolam), alprazolam (alprazolam) (diazepam), zolpidem, muscle relaxants, and analgesics and painkillers (such as codeine).

Check the labels on all your medicines (such as allergies or cough and cold medicines) because some of them are made up of substances that cause drowsiness. Ask your pharmacist how to use them so that you can use them safely.

Smoking lowers imipramine blood levels. Tell your doctor if you smoke or have recently stopped smoking.

Imipramine is very similar to desipramine. Do not use desipramine-containing medicines with imipramine.

Tips to consider before taking imipramine

Some medications can not be prescribed under certain conditions, and some medications may be prescribed if additional treatment is needed. Therefore, it is best for your doctor to be aware of the following before taking imipramine:

• If you are pregnant or breast-feeding.
• If you have thyroid problems.
• If you have liver or kidney disease.
• If you have epilepsy and diabetes.
• If you have constipation and have been suffering from it for several days.
• If you have difficulty passing urine or if you have prostate problems.
• If you have heart problems.
• If you have a mental disorder.
• If you have glaucoma.
• If you have pheochromocytoma (a benign tumor on the adrenal gland).
• If you have porphyria (a rare and inherited blood disorder).
• If you are currently taking certain medications. These include all available medicines, whether prescribed or used by your doctor, such as herbal medicines and supplements.
• If you have ever been allergic to any medication.

Possible side effects of imipramine

All medications, along with their positive effects, can cause unwanted side effects in the body. However, these complications do not occur in all people. Over time, your body will adjust to the new medicine and these symptoms will go away, but if the following symptoms persist or become painful, consult your doctor.

• Feeling dizzy, weak: Slowly getting up helps reduce this complication. If you feel weak, lie down for a few minutes to get rid of this condition.
• Feeling tired, blurred vision: In this situation, avoid driving and working with tools.
• Dry mouth: Chew sugar-free gum.
• Constipation: Eat a balanced diet. And drink several glasses of water daily.
• Headache: Ask your doctor to prescribe a suitable painkiller.
• Sweating, anxiety, difficulty sleeping, tingling sensation, breast tenderness, tremors, sexual dysfunction, changes in weight and appetite, difficulty urinating, hot flashes, mood swings: In these cases Consult your doctor.

Talk to your doctor if you have any other symptoms that you think may be due to imipramine.

How to store imipramine

• Keep the medicine in a cool, dry place away from heat and direct sunlight.
• Keep all medicines out of the reach of children.