Pyridostigmine

 

 

General English name: Pyridostigmine

Trade Name: Mestinon

Application: Myasthenia gravis

 

 

 

Pharmacological forms of pyridostigmine

Pharmacological information of pyridostigmine

Dosage and method of administration of pyridostigmine

Contraindications to pyridostigmine

Pyridostigmine use during pregnancy and lactation

The effect of pyridostigmine on driving and working with machines

Drug Interactions Pyridostigmine

Special warnings and precautions while taking pyridostigmine

Side effects of pyridostigmine

Overdose of pyridostigmine (drug poisoning)

Storage conditions of pyridostigmine

 

 

 

 

Pharmacological forms of pyridostigmine

Tablet

 

Pharmacological information of pyridostigmine

Pyridostigmine is the most commonly prescribed anticholinesterase for myasthenia gravis. Myasthenia gravis is a disease that must be tired and weakened. In this disease, you have created problems in transmitting nerve messages from the nerves to your muscles, and you have done this so that your muscles do not become stimulated and contracted. In this disease, the muscles in the eye were initially affected. Myasthenia gravis is an autoimmune disease. This means that the immune system (which protects your body from infection) has mistakenly attacked itself.

Your brain normally sends messages to the muscles by releasing a chemical called acetylcholine from the nerve endings. Acetylcholine rapidly attaches to small areas on the muscles (acetylcholine receptors) and this causes the muscles to contract. In most people with myasthenia gravis, the immune system blocks or damages these acetylcholine receptors. Acetylcholine can no longer bind to its receptor and therefore the muscle is less able to tighten.

Pyridostigmine works by reducing the breakdown of acetylcholine when released from the nerve endings. This means that there is more acetylcholine to bind to muscle receptors, which increases the strength of your muscles.

 

Dosage and method of administration of pyridostigmine

Read the package leaflet carefully before starting treatment with pyridostigmine. This brochure will help you to get comprehensive information about the drug and its possible side effects.

The dose and amount of pyridostigmine varies from person to person depending on the disease; Use the medicine exactly as your doctor advised. The dose of this medicine should be taken exactly and according to the doctor's prescription. Pyridostigmine is usually given to adults as 2-0.5 tablets a day. It takes 30-60 minutes for the tablets to start working and their effect lasts for about 4-6 hours. Take the pills at regular intervals (for example, early in the morning and before meals) when you are very active and need your muscles to be strong. When pyridostigmine is given to a child, the dose of the drug is calculated according to the age of the child.

Swallow the tablet with some water.

If you forget to take your daily dose at the right time, take it whenever you can; If you do not soon remember that you should take your medicine, do not take the missed dose. You should not take two doses of the medicine together because of the missed dose.

 

Contraindications to pyridostigmine

  • Note the expiration date of pyridostigmine and do not take it if it has expired.
  • Never give pyridostigmine to another person, even if you have the same symptoms.
  • Check for drug interactions, and if you are taking a drug that interacts with this medication, talk to your doctor about using your medications.

 

Pyridostigmine use during pregnancy and lactation

During pregnancy and lactation, you should not use the drug arbitrarily without consulting your doctor. Medications can have devastating effects on the fetus or on yourself.

 

The effect of pyridostigmine on driving and working with machines

Although this medicine does not make you drowsy, make sure you are alert before driving or operating machinery.

 

 Drug Interactions Pyridostigmine

Drug interactions may alter drug performance and increase the risk of serious side effects. Make a list of all the medicines (including prescription / over-the-counter and herbal medicines) you use and share them with your doctor and pharmacist. Do not change the dose of your medicine without consulting your doctor or stop taking the medicine.

 

Special warnings and precautions while taking pyridostigmine

Some medications may not be prescribed under certain conditions, and some medications may be prescribed if additional treatment is needed; Therefore, it is best to let your doctor know the following before taking the medicine:

  • If you are pregnant or breast-feeding.
  • If you have any kidney problems.
  • If you have a heart problem such as a slow heartbeat or a history of heart attack.
  • If you have a condition such as epilepsy, Parkinson's, hyperthyroidism or difficulty urinating.
  • If you have asthma.
  • If you have a stomach ulcer.
  • If you feel that you have an intestinal obstruction.
  • If you are taking certain medications. These medicines include all the medicines available, whether you are prescribed them or taking them without a doctor's prescription, such as herbal medicines and complementary medicines.
  • If you have a history of an allergic reaction to a drug.

 

Side effects of pyridostigmine

All medications can cause side effects. But many consumers also do not experience any side effects. Some of the side effects go away shortly after taking the medicine. In case of persistent side effects, the physician should be informed:

  • Increased saliva
  • Diarrhea
  • Heartburn and intestinal cramps
  • Feeling sick, nauseous or vomiting
  • Consult your doctor if you have any other symptoms that you feel may be due to pyridostigmine.

 

Overdose of pyridostigmine (drug poisoning)

Do not take more than the dose prescribed by your doctor.

If you feel that a person has drug poisoning and symptoms such as mental and mood changes (such as numbness, confusion, hallucinations), rapid or slow heartbeat, muscle cramps and weakness, inability to move, difficulty breathing, shortness of breath or fainting and If you see weakness in him, call the emergency services immediately.

 

Storage conditions of pyridostigmine

  • Keep the medicine out of the reach of children.
  • Keep the medicine in a cool, dry place away from heat and direct sunlight.
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