Co-Codamol and Ibuprofen


co-codamol and ibuprofen


Back pain, toothache, headache, etc. are somehow intertwined with our daily lives. Pain that doesn't requires urgent care at a medical center is usually not life threatening. But sometimes they become so annoying that they interfere with our daily activities. In this article, we intend to introduce two common painkillers, i.e. Ibuprofen and Co-Codamol or Acetaminophen. What you will read next:


1- Co-Codamol

     Use cases of Acetaminophen

    Precautions for Acetaminophen

    Acetaminophen intake

    Acetaminophen Poisoning

    When to see a doctor?

    Acetaminophen's anti inflammatory properties

    Side effects of Acetaminophen codeine

    Contraindications of Acetaminophen

    Safe dose of Co-Codamol


2- Ibuprofen

    Side effects of Ibuprofen

    Contraindications to Ibuprofen

    Dosage of Ibuprofen


1- Co-Codamol:

It is a combination of Acetaminophen (paracetamol) and codeine, also called Co-Codamol or codeine Acetaminophen. It is an analgesic drug. 

Application of Acetaminophen:

Acetaminophen is known as a fever reliever. Acetaminophen is also used to relieve mild to moderate pain, muscle aches, headaches, premenstrual pain, toothache, etc. If the pain is not very severe, acetaminophen dosage can be reduced to five hundred milligrams daily.

Precautions for Acetaminophen:

If you have liver failure and cirrhosis, or if you are allergic to acetaminophen or in case of pregnancy and lactation, be sure to consult with your doctor before taking this drug.

Acetaminophen intake:

The allowable dose of Acetaminophen in a healthy adult who does not drink alcohol and does not have liver disease is a maximum of seven and a half grams. In people with liver disease and people addicted to alcohol, this amount is much lower.

Acetaminophen Poisoning:

Poisoning due to the toxic dose of Acetaminophen has four stages:

First stage:

Within half an hour to twenty-four hours after taking the drug and begins with vomiting, sweating and anorexia.

Second stage:

After the first day until the end of seventy-two hours of taking the drug, there is abdominal pain and tenderness of the abdomen when touched.

Third stage (fourth day of taking the drug):

liver function has impaired accompanied by nausea and vomiting, jaundice and renal failure. It can be followed by decreased level of consciousness, heart muscle damage, coma and even death. If the patient survives this phase, the liver damage caused by acetaminophen will be recovered and healed automatically.

Therefore, Since the consequences can be severe, do not take more acetaminophen than allowed. Do not make the drug available to children and people with sensory impairments.

When to see a doctor?

Remember, if you are taking acetaminophen or paracetamol due to pain, see your doctor if you notice the following conditions and symptoms:

  • If your pain lasts for more than ten days while taking acetaminophen (more than five days in children)
  • If a new symptom is added to the pain
  • If the fever persists or worsens for more than three days despite receiving acetaminophen and in case of experiencing nausea and vomiting while taking paracetamol

The Acetaminophen does not have anti inflammatory properties

Acetaminophen is an analgesic drug that sometimes its analgesic properties are enhanced by adding codeine. Acetaminophen codeine, or co-codamol, is used to relieve moderate to severe pain.

The ratio of acetaminophen to codeine varies from country to country. There are 300 or 100 mg combinations of acetaminophen with 8 mg of codeine in the global market, and larger quantities can only be sold with doctor's prescription.

Side effects of acetaminophen codeine:

Acetaminophen codeine has the following side effects:

  • Constipation
  • Respiratory depression
  • Low blood pressure
  • Impaired consciousness (Avoid driving and engaging in activities that require alertness while taking this medicine)

Contraindications of Acetaminophen:

Both components of the drug can be secreted in milk and reach the infant, so avoid taking this drug during breastfeeding. Acetaminophen is contraindicated in children under 12 years of age. Moreover, Acetaminophen codeine is contraindicated in patients with severe asthma attacks.

Safe dose of Co-Codamol:

In adults:

  • Acetaminophen (one hundred to three thousands) mg per dose
  • And codeine (fifteen to sixty mg) per dose
  • Every four hours
  • The maximum allowable dose of acetaminophen in an adult human is about four grams every twenty-four hours and codeine is three hundred and sixty milligrams.

In children:

It is forbidden for children under 12 years of age or people under 18 years of age who have had tonsillectomy. 


2- Ibuprofen

With the introduction of Non-Steroid Anti-Inflammatory Drugs (NSAIDS), especially Ibuprofen, Co-Codamol consumption has decreased substantially.

Ibuprofen is used to reduce inflammation and relieve menstrual cramps and gout. Ibuprofen has anti-fever, anti-inflammatory and analgesic properties and this happens by inhibiting the enzyme cyclooxygenase (non-selectively inhibit type one and two). These enzymes are involved in the production of prostaglandins, which are important mediators of inflammatory processes in the body.

Prostaglandins made by the enzyme cyclooxygenase one are very important for the protection of our gastric mucosa, so a group of NSAIDS that inhibit the enzyme cyclooxygenase one and two, if used continuously, especially in smokers or people with a history of bleeding and gastric ulcer will be dangerous.

Side effects of ibuprofen:

Most common side effects of ibuprofen are:

  • Stomachache
  • Gastritis
  • Nausea
  • Vomit
  • Diarrhea
  • Constipation (in combination with codeine)

Ibuprofen, like the rest of the family, increases the risk of fatal heart attacks and strokes, so avoid taking these medications if you have underlying cardiovascular disease or have recently had CABG. Taking these medications in the weeks leading up to surgery, in particular cardiac bypass surgery, is prohibited.

Contraindications of ibuprofen:

Consult your doctor before taking the medicine if you have any of the following:

Permissible dosage of ibuprofen:

Overuse of ibuprofen can cause fatal gastrointestinal bleeding. The permissible dose of ibuprofen for healthy adults is 800 mg per dose. And the maximum dose that could be use is four grams a day.

Advil, Midol, Motrin, are other names for ibuprofen. The combination of ibuprofen plus codeine is now available in the pharmaceutical market under the name (Nurofen Plus). Do not use this mixture arbitrarily for more than three days.




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