Amitriptyline

General English name: Amitriptyline

Application: Depression, nerve pain

 

 

Amitriptyline Pharmacological Information

Medication Information: Amitriptyline belongs to a group of drugs called tricyclic antidepressants. These drugs used to be prescribed to treat depression, but are rarely used today; But they take precedence over other drugs.

Although amitriptyline is prescribed to treat depression, it is also prescribed to help reduce certain types of nerve pain as well as to help prevent migraines. Consult your doctor if you have any questions about treatment with amitriptyline.

 

Contraindications to the use of amitriptyline

Pay attention to the expiration date of amitriptyline and do not take the medicine if it has expired.

Never give amitriptyline to anyone else, even if you have the same symptoms.

Do not take more amitriptyline than the dose prescribed by your doctor.

Check for amitriptyline drug interactions and be sure to tell your doctor what other medications you are taking.

Amitriptyline is hypnotic, avoid driving while taking this drug.

Drug interaction of amitriptyline

It may alter the performance of medications and increase the risk of serious side effects. Make a list of all the medicines (including prescription / over-the-counter medicines and herbal products) you use and share them with your doctor and pharmacist. Do not change the dose of your medicine without consulting your doctor or stop taking the medicine.

 

Drug interaction of amitriptyline

It may alter the performance of medications and increase the risk of serious side effects. Make a list of all the medicines (including prescription / over-the-counter medicines and herbal products) you use and share them with your doctor and pharmacist. Do not change the dose of your medicine without consulting your doctor or stop taking the medicine.

Some medications that may interact with amitriptyline include arbutamine, disulfiram, thyroid supplements, and medications that can cause bleeding or bruising (including antiplatelet drugs such as clopidogrel, clopidogrel). Non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, blood-thinning drugs such as warfarin, anticholinergic drugs such as benztropine, belladonna alkaloids, and certain antihypertensive drugs. Such as clonidine, guanabenz, reserpine.

Amitriptyline can cause serious drug interactions with MAO inhibitors, which can even lead to death, along with amitriptyline from MAO inhibitors (isocarboxazid), linezolid, methylene blue, methylene blue, methylene blue Do not use phenelzine, procarbazine, rasagiline, selegiline, tranylcypromine. Most MAO inhibitors should not be used until 2 weeks before the start of amitriptyline.

Drugs that can affect the removal of amitriptyline from the body and affect its function include: cimetidine, terbinafine, and irregular heartbeat medications (such as quinidine) / propafenone / flecainide (flecainide), antidepressants (such as SSRIs including paroxetine / fluoxetine / fluvoxamine), although this is not a complete list; So before taking amitriptyline, make a list of all the medicines you use and share it with your doctor and pharmacist.

Many drugs in addition to amitriptyline may affect heart rhythm (prolongation of QT time), including: amiodarone, dofetilide, pimozide, procainamide, quinidine ), Sotalol, macrolide antibiotics (such as erythromycin).

Tell your doctor or pharmacist if you are taking medicines that cause drowsiness, including: alcohol, antihistamines (such as cetirizine, diphenhydramine), sleeping pills or anxiety medications (such as alprazolam), alprazolam (alprazolam) (diazepam), zolpidem, muscle relaxants, and analgesics and painkillers (such as codeine).

Check the labels on all your medicines (such as allergies or cough and cold medicines) because some of them are made up of substances that cause drowsiness. Ask your pharmacist how to use them so that you can use them safely.

Aspirin can increase the risk of bleeding if taken with amitriptyline. However, if your doctor prescribes low-dose aspirin (usually 325-81 mg per day) to prevent a stroke or heart attack, you should continue to take it unless your doctor tells you to stop taking it. Give aspirin. Consult your pharmacist for more details.

Taking a number of medications with amitriptyline may increase the risk of seizures, including isoniazid (INH), phenothiazines (such as thioridazine), theophylline, or tricyclic antidepressants (such as nortriptyline). (nortriptyline)).

Amitriptyline is very similar to nortriptyline. Do not use nortriptyline-containing medicines with amitriptyline.

 

Tips to consider before taking amitriptyline

Some medications are not suitable for people with certain conditions, and some medications may be prescribed if additional treatment is needed; Therefore, it is best for your doctor to be aware of the following before taking amitriptyline:

•  If you are pregnant or breast-feeding.
•  If you have an overactive thyroid.
•  If you have a liver problem.
•  If you have epilepsy or diabetes mellitus.
•  If you have constipation.
•  If you have trouble passing urine or prostate.
•  If you have a cardiovascular problem.
• If you have ever had a mental health problem (especially bipolar disorder or psychosis).
•  If you have high blood pressure (glaucoma).
•  If you have a disease called pheochromocytoma (tumor of the adrenal gland).
•  If you have a condition called porphyria (a rare inherited blood disorder).
•  If you are taking certain medications. These medicines include all the medicines available, whether you are prescribed them or taking them without a doctor’s prescription, such as herbal medicines and complementary medicines. Especially if you are taking an antidepressant (monoamine oxidase inhibitor).
•  If you have a history of an allergic reaction to a drug.

 

Possible side effects of amitriptyline

All medications can cause side effects; But many consumers do not experience any side effects. Some of the side effects go away after a short time of taking the medicine. In case of continuous occurrence of any side effects, the physician should be informed:

Dry mouth, drowsiness, blurred vision, sickness, diarrhea, abdominal pain, dizziness when getting up, constipation, anxiety and confusion, sleep, urinary problems, tingling sensation, breast tenderness, sexual problems Changes in appetite and weight, changes in the taste of food and taste, ringing in the ears, itchy skin rash, hair loss, increased sweating, changes in heart rate or heart rhythm

 

How to store amitriptyline

Keep all medicines out of the reach of children.

Keep the medicine in a cool, dry place away from heat and direct sunlight.