General English name: Bosentan

Brand: Tracleer

Application: Pulmonary artery blood pressure – Wound prevention in people with systemic sclerosis


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Bosentan Drug Information

Medication Information: Pulmonary artery hypertension (PAH) is a disease in which the blood pressure of the blood vessels feeding the lungs is too high. Bosentan relaxes the muscle cells in the walls of the blood vessels that lead to your lungs, allowing your blood vessels to dilate. This reduces the pressure in the blood vessels and makes the blood flow in the blood vessels easier. As a result, your lung function and ability to exercise will improve.

Bosentan is also prescribed for people with autoimmune disorders called systemic sclerosis. It is a disorder of your immune system (which normally protects your body) that causes damage to the connective system. Some people with systemic sclerosis develop certain symptoms (sores on their fingertips). This sore can be painful and difficult to heal. Bosentan can also help prevent new wounds. Bosentan is prescribed for you by a specialist doctor.


Contraindications to the use of Bosentan

Pay attention to the expiration date of the medicine and do not take it if the medicine in your hand has expired.

Never give the medicine to anyone else, even if you have the same symptoms.

Do not take more than the dose prescribed by your doctor.

Check for drug interactions and be sure to tell your doctor what other medications you are taking.


Bosentan drug interactions

Drug interactions may alter drug performance and increase the risk of serious side effects. Make a list of all the medicines (including prescription / over-the-counter medicines and herbal products) you use and share them with your doctor and pharmacist. Do not change the dose of your medicine without consulting your doctor or stop taking the medicine.

Some medications that may interact with Bosentan include cyclosporine and glyburide.

Other drugs that can affect the removal of bosentan from the body and affect the function of this drug include: amiodarone, cimetidine, tacrolimus, St. John’s wort, anticonvulsants (such as carbamazepine). Azole antifungals (such as itraconazole, ketoconazole), macrolide antibiotics (such as erythromycin), HIV protease inhibitors (such as ritonavir), rifamycins (such as rifabutin).

Bosentan can affect the rate at which other drugs are eliminated from the body and affect how the drugs work. Examples of affected drugs include cholesterol “statin” drugs (such as simvastatin, lovastatin), warfarin, specific combination drugs for the treatment of chronic hepatitis C (ombitacoure / paritaproir / ritonavir).

Bosentan may reduce the effectiveness of hormonal contraceptives such as pills, patches, or rings. This can lead to pregnancy. Talk to your doctor about a reliable method of birth control and use an effective method (latex condom or polyurethane) to control pregnancy throughout your sexual activity. Talk to your doctor if you have severe spotting or bleeding, as this may be a sign that your hormonal pregnancy control is not working well.


Tips to consider before taking Bosentan

Some medications are not suitable for people with certain conditions, and some medications may be prescribed if additional treatment is needed; Therefore, it is better for your doctor to know the following before taking Bosentan:


Possible side effects of Bosentan

All medications can cause side effects; But many consumers also do not experience any side effects. In case of continuous occurrence of any of the complications, the physician should be informed:

Headache, swelling of the feet or ankles, fluid retention, dizziness, gastric reflux, diarrhea, palpitations, hot flashes, allergic reactions such as itchy red rash, changes in the results of some blood tests

Talk to your doctor if you have any other symptoms that you think may be due to your Bosentan medicine.


How to store Bosentan

Keep all medicines out of the reach of children.

Keep the medicine in a cool, dry place away from heat and direct sunlight.