General English name: Busulfan
Brand: Myleran
Application: Treatment of chronic myeloid leukemia – preparation for stem cell transplantation
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Busulfan drug Information
Drug Information: Busulfan is used to treat chronic myeloid leukemia (CML). It is a cancer of the blood-forming cells in the bone marrow. Abnormal cells gradually fill the bone marrow and leak into the bloodstream, increasing your white blood cell count. The disease usually develops slowly, and symptoms such as anemia, bleeding problems, or infection do not occur for years after the onset of the disease.
Busulfan is used to prepare a person for a stem cell transplant. In this transplant, growing blood cells in a healthy bone marrow are transferred to another person to produce healthy cells in that person’s bone marrow.
Busulfan stops cell proliferation. It works by binding to and damaging the cell’s DNA, thus preventing an increase in the number of blood cells.
Contraindications to the use of the drug Busulfan
Pay attention to the expiration date of Busulfan and do not take it if it has expired.
Never give the medicine to anyone else, even if you have the same symptoms.
Do not take more than the dose prescribed by your doctor.
Check for drug interactions and be sure to tell your doctor what other medications you are taking.
Drug Interaction with Busulfan
Drug interactions may alter drug performance and increase the risk of serious side effects. Make a list of all the medicines (including prescription / over-the-counter medicines and herbal products) you use and share them with your doctor and pharmacist. Do not change the dose of your medicine without consulting your doctor or stop taking the medicine.
Some medications that may interact with busulfan include acetaminophen, itraconazole, metronidazole, and thioguanine.
Taking certain medications with busulfan may increase the risk of seizures, including tramadol, phenothiazines (such as thioridazine), theophylline, and tricyclic antidepressants (such as amitriptyline).
Tips to consider before taking Busulfan
Some medications may not be prescribed under certain conditions, and some medications may be prescribed if additional treatment is needed; Therefore, it is best for your doctor to be aware of the following before taking busulfan:
- If you are pregnant or planning to have a baby or are breastfeeding your baby.
- If you have recently had radiotherapy.
- If you have any liver or kidney problems.
- If you have an infection or illness.
- If you have porphyria (a rare inherited blood disorder).
- If you are currently taking certain medications. These medicines include all the medicines available, whether you are prescribed them or taking them without a doctor’s prescription, such as herbal medicines and complementary medicines.
- If you have a history of an allergic reaction to a medicine.
Possible side effects of Busulfan
All medications can cause side effects; But many consumers also do not experience any side effects. Some of the side effects go away shortly after taking the medicine. In case of continuous occurrence of any side effects, the physician should be informed:
Feeling sick, diarrhea, mouth sores, hair loss, patches or dark patches on the skin, menstrual problems, feeling sick, fever or signs of infection, sudden bruising or bleeding, sudden wheezing or any difficulty breathing, Jaundice (yellowing of the skin or whites of the eyes)
Consult your doctor if you have any other symptoms that you feel are due to the use of busulfan.
How to store Busulfan
Keep all medicines out of the reach of children.
Keep the medicine in a cool, dry place away from heat and direct sunlight.