Are you aware of the negative effects of smoking on the liver?

Smoking can damage liver tissue. What is the damage to the liver after smoking?

In the following, we want to talk more about the harms of smoking in the liver.


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Liver plays a very important role in detoxifying the body. Prepared foods with high sugar, Low protein and high carbohydrate diets, High fat foods rich in saturated fats, nicotine, cigarettes and caffeine and many food additives can damage the liver. A liver that does not work properly causes lethargy and fatigue, nausea and vomiting in the person.

In liver damage, smoking, including cigarettes, should be stopped and proper diet and medication should be applied to stop the process of cell damage in the early stages (for example, the early stages of fatty liver).


What are the damages to the liver caused by smoking?

The following are three major effects of smoking on the liver:

First effect) Toxic effects (hepatotoxic) that are direct or indirect.

Second effect) Immunological effects

Third effect) Oncogenic effects

(That is, it causes cancer in this tissue)

One of the effects of smoking in smokers is that a number of chemicals are released into the bloodstream after smoking, which have a high latent potential and can cause necroinflammation and fibrosis of liver tissue.


Does smoking damage your liver?

Studies show that there is a direct link between smoking and liver problems.

Smoking is one of the main risk factors for liver cell damage and inflammation. Smoking is one of the main risk factors for the onset of fatty liver disease. In fact, smoking initiates and aggravates fatty liver disorders in people who do not drink alcohol.


Can it be said that laboratory data on liver function or LFT are altered by smoking?

Yes, smoking can alter LFT laboratory results.


Smoking can have many negative and destructive effects on various organs of the body. Many of those who are affected by the effects of smoking have not smoked themselves.

In this article, we want to talk about the effects that smoking has on your liver:


What effects does smoking have on the liver?

The changes that occur in the liver due to smoking are varied, but in order to better understand, we must say that smoking causes three different and important effects on the liver.

  1. The first effect is a direct or indirect toxic effect
  2. The second effect is immunological effects
  3. The third effect is oncogenic effects


It is said that when a person smokes, the chemicals that enter the body and bloodstream through smoking have many cytotoxic potentials that can increase the risk of necroinflammation and fibrosis in the body.

The second effect:

Increased production of interleukins and proinflammatory cytokines such as interleukin 1, interleukin 6, and tnf alpha, can cause liver damage at the cellular level.


The next effect that smoking can have on liver tissue is the development of secondary polycythemia. Secondary occurs in response to hypoxia in the blood following smoking.

In A person with polycythemia the number of red blood cells increases, so it is possible for a person to have a secondary increase in iron load, ie a person is prone to iron overload disorder.

The increase in iron in our body is considered as an oxidative factor and in fact an interleukin to initiate oxidative stress in tissues. Hepatocytes, are severely affected by this stressor and oxidative factor and will be damaged.

Another effect of the body following a secondary polycythemia following smoking is that when the number of red blood cells in the blood increases, their turn over increases.

This process is associated with increased amino acid catabolism called purine, and in fact when too much purine is produced when it is to be excreted from the body it will greatly stimulate the production of uric acid.

Leaving aside the direct cytotoxic effects of nicotine and smoking on the liver, we come to the second effect of the second group, which was in fact the effects on our immune system.

Smoking can affect both cellular and hemorrhagic immune pathways. In fact, smoking causes the immune system to reduce the proliferation of lymphocytes.

Smoking also increases the induction of apoptosis in living lymphocytes.

So, we have to say that the effect of smoking on the immune system is that it involves every humoral immune system and all the cells. Cigarettes can block the proliferation of lymphocytes with their oxidative agents and in turn induce lymphocyte apoptosis.

Another effect of smoking on the liver is that smoking increases the amount of iron accumulated in the liver and serum itself, Thus, the accumulation of iron causes oxidative stress to enter the tissue and increases the peroxidation of fats, which in turn increases the activation of a group of cells that leads to increased fibrosis of tissues, including liver tissue.

Another effect of smoking on the liver;

Smoking increases the risk of hepatocellular carcinoma in patients who smoke and have viral hepatitis.

It also puts smokers who have not had a viral infection at all (smokers without viral hepatitis) at higher risk for developing hepatocellular carcinoma HCC.

Hepatocellular carcinoma has been shown to increase significantly in both smokers with viral hepatitis and non-hepatitis smokers.

Tobacco has been shown to suppress tumor suppressor of an important gene called p53.

It has also been widely reported that people who have been heavy smokers with viral hepatitis and have received interferon therapy have received inadequate virological responses that have improved by performing phlebotomy.

A term “smokers’ syndrome” In fact, is a clinical condition that patients from different episodes complains of flushing face, warm palms and soles of the feet and severe headaches, Feeling full and heavy on the head and face, Lightness of the head, fatigue as well as muscle aches and hives.

Another point we have to point out is that even cigarettes sold as light cigarettes contain over 4,000 harmful chemicals that can have very severe effects on all organs of the body. The effects of smoking on the pathogenesis of liver disease as well as the response to treatment of chronic hepatitis has also been highly evident in studies.

Learn about another irreversible effect of smoking on the liver:

Smoking increases the resistance of the body’s cells to insulin by acting on the insulin receptors on the cells. Increasing the body’s resistance to insulin causes the blood sugar to be out of control. eventually they all have a direct effect on the aggravation of fatty liver. It is said that when insulin resistance develops, the inflammation of the liver cells and their inability to purify fats is much more evident.

This means that people with insulin resistance are more likely to develop fatty liver. On the other hand, smoking accelerates the inflammation of liver cells and the development of fatty liver.


What is the link between fatty liver and smoking?

It is said that when you use tobacco products that contain tobacco or products that contain nicotine, neurotransmitters called catecholamines are released into the bloodstream, this causes the release of fat in fat cells. The released fat flows into the bloodstream, and in this way, the process of atherosclerosis and clogged arteries is intensified and one of the consequences of the above set will be the formation of fatty liver.


What are the risk factors for fatty liver?