General English name: Metyrapone

Brand: Metopirone

Application: Diagnosis or treatment of Cushing’s syndrome – treatment of fluid retention associated with some kidney, liver and heart diseases

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Methirapone drug forms


Methirapone drug information

Methirapone is a drug that can be used to diagnose Cushing’s syndrome and is also sometimes prescribed to treat Cushing’s syndrome. Cushing’s syndrome is a condition in which the level of a substance called cortisol in your body is too high for a long time. Cortisol is a hormone that is released during times of stress to maintain normal body condition. It also regulates blood pressure, the immune system and blood sugar levels. Normally your body keeps cortisol levels in a certain range so that it is neither too much nor too little. When too much cortisol is produced, symptoms such as weight loss, muscle weakness and bruising occur. Metyrapone inhibits cortisol secretion and helps control these symptoms.

Methirapone is used to treat some types of water retention (edema) caused by an increase in a hormone called aldosterone. This type of water retention may occur due to kidney problems, liver cirrhosis or heart failure. Water retention can cause swelling of the feet, ankles and face.

The correct amount and method of taking Metyrapone

Contraindications to methirapone

Note the expiration date of Methirapone and do not take it if it has expired.

Never give Metyrapone to another person, even if you have the same symptoms.

Check for drug interactions with methirapone, and if you are taking a drug that interacts with this drug, talk to your doctor about using your medications.

Methirapone during pregnancy and lactation

During pregnancy and lactation, you should not use the drug arbitrarily without consulting your doctor. Methirapone during pregnancy may be dangerous for the fetus.

The effect of taking Metyrapone on driving

Methirapone can cause dizziness and drowsiness. Avoid driving until these symptoms have resolved.

Methirapone drug interaction

Drug interactions may alter drug performance and increase the risk of serious side effects. Make a list of all the medicines (including prescription / over-the-counter and herbal medicines) you use and share them with your doctor and pharmacist. Do not change the dose of your medicine without consulting your doctor or stop taking the medicine.

Some medications that may interact with methirapone include acetaminophen, cyproheptadine, estrogen, and hydantoin (such as phenytoin).

If you are taking corticosteroids (such as hydrocortisone, prednisone), these medications should be stopped before and during the metirapone test. Consult your doctor for more details on how to do this.

Metyrapone Warning

Some medications may not be prescribed under certain conditions, and some medications may be prescribed if additional treatment is needed; Therefore, it is best for your doctor to be aware of the following before taking methirapone:

Side effects of methirapone

All medications can cause side effects. But many consumers also do not experience any side effects. Some of the side effects go away shortly after taking the medicine. In case of persistent side effects, the physician should be informed:

feeling sleepy


Feeling sick, nausea

Feeling weak and dizzy

Consult your doctor if you have any other symptoms that you feel may be due to Metyrapone.

Complications of Metyrapone Overdose (Metyrapone Poisoning)

Do not take more than the dose prescribed by your doctor.

If you feel that someone has been poisoned and you have symptoms such as a fast or irregular heartbeat, severe dizziness, anxiety, confusion, weakness, vomiting, stomach pain, shortness of breath, fainting and weakness (fainting), call the emergency room right away. Call.

Storage conditions of Metyrapone

Keep the medicine out of the reach of children.

Store the medicine in a cool, dry place away from heat and direct sunlight.

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