About seventy-six percent of people with chronic liver disease have low platelet counts, thrombocytopenia, or decreased blood flow platelets due to liver disorders. May occur with jaundice due to hepatic impairment.
Read more about jaundice and low platelets:
what you will read next :
- What causes thrombocytopenia or low platelets in chronic liver disease?
- What are the side effects of platelet depletion?
- What are the other symptoms of liver failure or cirrhosis?
- What are gastrointestinal varicose veins?
- Can platelet depletion itself lead to jaundice?
- What is the reason for this association between low platelets and jaundice?
More than 76 percent of patients with chronic liver disease or CLD have a platelet count of less than one hundred and fifty thousand per microliter of blood, thirteen percent of patients with cirrhosis or liver failure have a platelet count between seventy-five thousand to fifty thousand per microliter of blood Is.
What causes thrombocytopenia or low platelets in chronic liver disease?
- Trapping of blood platelets in the spleen and destruction of platelets in it or hypersplenism (spleen sequestration)
- Decreased platelet production in the bone marrow
- Decreased function of hematopoietic cell growth factors or hematopoietic factors that are essential for platelet stimulation and production. The factor that is needed for platelets to be made in the bone marrow is called TPO, which is made by a healthy liver. In chronic diseases and liver failure associated with jaundice, TPO production is greatly reduced.
- Increased venous pressure in the liver, which increases the trapping and destruction of blood platelets in the spleen.
What are the side effects of platelet depletion?
Decreased Platelet or thrombocytopenia is a marker that indicates advanced liver disease and disorder and is commonly seen in fibrosis or liver failure (liver cirrhosis) and liver disease with increased portal blood pressure. Gastrointestinal bleeding and intracranial hemorrhage are associated with dangerous conditions for a person with liver failure.
In short, chronic liver disease that leads to liver failure or cirrhosis in the advanced stages is clearly associated with a decrease in platelet count.
What are the other symptoms of liver failure or cirrhosis?
In the early stages of liver failure, the symptoms will be less and as the liver dysfunction progresses; the symptoms will become more and more serious. Including:
- nausea and vomiting
- Jaundice of the skin and sclera of the eyes
- Severe itching of the skin
- Abdominal dehydration or hepatic acidosis
- Upper and right abdominal pain
- Swelling of the feet and ankles
- Dementia and difficulty concentrating
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Therefore, it can be said that in liver failure or liver cirrhosis, there will be jaundice with low platelet count or thrombocytopenia.
One of the most dangerous and potential complications in patients with jaundice and platelet drop in chronic liver disease and hypertension of the portal vein of the liver is severe gastrointestinal bleeding that can be life threatening.
What are gastrointestinal varicose veins?
Varicose veins of the end of the esophagus and varicose veins of the stomach wall are twisted and full of blood vessels, which are very common in people with liver failure and hypertension of the hepatic vein, and are very prone to rupture. Low platelet counts, in turn, make gastrointestinal bleeding much more dangerous and severe.
Decreased platelets is a common symptom in chronic liver disease along with jaundice, which occurs for the following two main reasons:
- Decreased production of platelet growth factor (TPO) by the defective liver, which is necessary for platelet production.
- Trapping and destruction or phagocytosis of platelets in the spleen
Can platelet depletion itself lead to jaundice?
- The answer is yes. A person without thrombocytopenia may have thrombocytopenia, which means that the number of platelets in his blood is less than one hundred and fifty thousand per microliter of blood, and he may develop Jaundice of the skin and sclera of the eyes
What is the reason for this association between low platelets and jaundice?
One of the most important functions of platelets in our body is to prevent easy and excessive bleeding.
When the platelets are low, with each trauma, superficial dead blood is created under the skin. The so-called skin bruises easily. And in severe platelet depletion, internal bleeding, especially gastrointestinal bleeding, occurs easily.
Intracranial hemorrhage can be formed by gentle traumas to the head
When bleeding occurs in areas of the body such as the subcutaneous tissue, inside the joints, and inside the skull, red blood cells must be broken down and broken down in the process of their absorption, which is called RBC lysis.
As a result of RBC lysis, special compounds are created that must be cleared from the blood by the liver and poured into the intestine to be excreted in the feces. !!!!
When platelets are low and small bleeds occur regularly, the liver is unable to filter all of the RBC lysis substances from the blood, so some of this substance called bilirubin remains in the bloodstream and the skin and the sclera of the eyes turn yellow
Some viral infections, such as EBV infection, can also be associated with decreased platelets and sometimes jaundice.
There is also a rare disorder called hemolytic uremic syndrome, which is associated with increased degradation and lysis of RBCs and decreased platelet count. Excess bilirubin in the bloodstream may be associated with jaundice.