General English name: Natalizumab

Brand: Tysabri

Application: Multiple sclerosis – Crohn’s disease


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Natalizumb Pharmaceutical Forms

Injectable vial


Natalizumb Drug Information

Multiple sclerosis (MS) is a disease that affects the brain and spinal cord and causes the protective covering (myelin) around the nerves of the brain and spinal cord to be damaged in people with MS, making the nerves not working properly. Most people with MS have a recurrence or exacerbation of the disease over time. Symptoms of the disease occur or worsen in different parts of the body. The symptoms of a recurrence of the disease last for a period of time and then diminish. Natalizumbe is a monoclonal antibody that interferes with the work of the immune system, because it is responsible for causing nerve damage, and this reduces the recurrence of the disease in some people.

Natalizumab does not cure MS but reduces damage and reduces the risk of disability. This medicine will be prescribed by a specialist doctor and will monitor your treatment.

Natalizumab is also used to treat an intestinal condition called Crohn’s disease (CD) (when it is moderate to severe or relapsing). It is not intended for CD, but it is thought to prevent inflammation and swelling in the gut by interfering with the body’s immune system.


The correct amount and method of taking Natalizumab

Read the package leaflet carefully before starting treatment with this medicine. This brochure will help you to get comprehensive information about the drug and its possible side effects.

The dose and amount of Natalizumab varies from person to person; Use the medicine exactly as your doctor advised.

The drug is injected intravenously (every 4 weeks) intravenously (within 1 hour). The doctor monitors the patient’s symptoms for up to an hour after the injection.

Try not to miss a dose of Natalizumab.

If your condition does not improve after 12 weeks of natalizumbe, consult your doctor before taking the next dose.


Contraindications to natalizumbe


Natalizumbe use during pregnancy and lactation

During pregnancy and lactation, you should not use the drug arbitrarily and without consulting your doctor. Taking natalizumbe during pregnancy may be dangerous for the fetus.


The effect of taking Natalizumab on driving

Natalizumb does not cause dizziness, blurred vision or drowsiness, you do not need to avoid driving.


Natalizumb Drug Interaction

Drug interactions may alter drug performance and increase the risk of serious side effects. Make a list of all the medicines (including prescription / over-the-counter and herbal medicines) you use and share them with your doctor and pharmacist. Do not change the dose of your medicine without consulting your doctor or stop taking the medicine.


Natalizumab Warning

Some medications may not be prescribed under certain conditions, and some medications may be prescribed if additional treatment is needed; Therefore, it is best for your doctor to be aware of the following before taking natalizumbe:


Side effects of natalizumbe

All medications can cause side effects. But many consumers also do not experience any side effects. Some of the side effects go away after a short time of taking the medicine. In case of persistent side effects, the physician should be informed:

Redness and pain at the injection site

Swelling of hands, feet and ankles

Changes in the menstrual cycle

Severe and persistent headache, stiffness and pain in the neck, rapid heartbeat, symptoms of infection (such as fever, sore throat, respiratory problems, abnormal vaginal discharge, pain and frequent urination), mood swings (such as depression, suicidal ideation), severe stomach pain And abdomen, symptoms of liver problems (such as nausea, yellow skin and eyes, dark urine, weakness and fatigue): Consult your doctor if you have these rare symptoms.

Consult your doctor if you have any other symptoms that you feel may be due to Natalizumab.


Side effects of Natalizumab overdose (natalizumab poisoning)

Do not take more than the dose prescribed by your doctor.

If you feel that someone has been poisoned and you have symptoms such as shortness of breath, fainting and weakness (fainting), call the emergency room immediately.


Storage conditions of Natalizumab

Keep the medicine out of the reach of children.

Store the medicine in a cool, dry place away from heat and direct sunlight.