General English name: Tolvaptan

Brand: Samsca

Application: Treatment of hyponatremia or low blood sodium


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Tolvaaptan medicinal forms

Injectable solution


Toluaptan Medication Information

Toluaptan is a class of vasopressin receptor antagonists that help your body get rid of excess water by increasing the amount of urine it helps treat hyponatremia or low blood sodium (a condition caused by a heart or hormonal problem). he does. Toluaptan helps to slowly increase the normal amount of salt in the blood.


The correct amount and method of taking tolvaptan

Read the package leaflet carefully before starting treatment with this medicine. This brochure will help you to get information about the drug and its possible side effects.

The dose and amount of Tolvaptan varies from person to person; Use the medicine exactly as your doctor advised. Usually take this medicine once a day with or without food.

You should not take Tolvaptan for more than 30 consecutive days.

The dose of this drug depends on the patient’s condition and the effectiveness of the drug.

Drink water regularly to prevent dehydration due to increased urination.

Do not eat grapefruit while taking this medicine, as it aggravates the side effects of the medicine.

If you forget to take your dose at the right time, you should not take two doses at a time because of the missed dose.


Contraindications to the use of tolvaptan

Pay attention to the expiration date of your Tolvap medicine and do not take it if the medicine in your hand has expired.

Never give Tolvaptan to another person, even if you have the same symptoms.

Check for drug interactions with your Tolvap, and if you are taking a drug that interacts with this drug, talk to your doctor about using your medications.


Toluaptan during pregnancy and lactation

During pregnancy and lactation, you should not use the drug arbitrarily and without consulting your doctor.


The effect of Tolvaptan consumption on driving

Tolvaptan does not cause drowsiness, if you are not drowsy you do not need to avoid driving and working with machines.


Drug interactions of toluaptan

Drug interactions may alter drug performance and increase the risk of serious side effects. Make a list of all the medicines (including prescription / over-the-counter and herbal medicines) you use and share them with your doctor and pharmacist. Do not change the dose of your medicine without consulting your doctor or stop taking the medicine.

Tolvaptan may interact with desmopressin.

Other medicines may affect the removal of toluene from your body and may affect how it works; These include: Azole antifungals (such as ketoconazole, itraconazole), busprovir, cubicistat, HIV protease inhibitors (such as lupinavir, ritonavir), macrolide antibiotics (such as clarithromycin, ribosine, ribosibicin, ribosibicin) ), St. John’s wort, drugs used to treat seizures (such as carbamazepine, phenytoin), talapirovir.


Tolvaptan Warning

Some medications may not be prescribed under certain conditions, and some medications may be prescribed if additional treatment is needed; Therefore, it is best for your doctor to be aware of the following before taking Tolvaptan:


Side effects of taking tolvaptan

All medications can cause side effects. But many consumers also do not experience any side effects. Some of the side effects go away shortly after taking this medicine. In case of persistent side effects, the physician should be informed.

Decreased appetite


Dry mouth




Liver problems (liver cirrhosis)

Symptoms of liver problems such as heartburn, yellow or white eyes, nausea, dark urine: See your doctor if you have any of these symptoms.

Symptoms of allergies such as skin rash and shortness of breath

Consult your doctor if you have any other symptoms that you feel may be due to Tolvaptan.


Side effects of Tolvaptan overdose (Tolvaptan poisoning)

Do not take more than the dose prescribed by your doctor.

If you feel that someone has been poisoned and you have symptoms such as shortness of breath, fainting and weakness (fainting), call the emergency room immediately.


Storage conditions of Tolvaptan

Keep the medicine out of the reach of children.

Store the medicine in a cool, dry place away from heat and direct sunlight.

Store the injectable solution at room temperature.